Turning CCIT from a regulatory requirement into a real benefit — for packaging integrity, compliance, and patient safety is our mission

Your advantage

Benefit from the expertise of be integral GmbH, founded by Jens Höllein in 2022 as the only independent European consultancy focused entirely on leak-proofing and container closure integrity (CCIT) for parenteral packaging.

We guide pharmaceutical companies through the dense landscape of regulations and global authority expectations. Working directly with your team, we ensure that your packaging systems meet all approval requirements — and that your medicines remain sterile and effective throughout their lifecycle.

With the support of our additional laboratory services, you don’t just gain solutions — you build lasting in-house expertise.

Let’s talk about how we can support your packaging challenge.

Asking for advice is free. Receiving advice is inexpensive — and the potential savings can be substantial.

If nothing new comes from our conversation, your investment will have been just a few minutes preparing your request and half an hour discussing your issue.

#CCIT

Container Closure Integrity Testing (CCIT) assesses whether a primary packaging system reliably maintains its seal — protecting not only the product, but also the patient, the user, and the environment.

Integrity is essential to ensure sterility, stability, and safe handling of parenteral drugs. The container must prevent leaks, microbial ingress, and the intrusion of gases such as oxygenand moisture, which can degrade sensitive formulations.

But CCIT is more than a regulatory requirement. It’s a powerful process insight tool. Properly implemented, CCIT helps you detect risks early, identify process drift, and respond before quality is compromised.

Trending shifts in CCIT data are never random — they are early warnings. Failures don’t come from good processes. That’s why doing CCIT right doesn’t just satisfy compliance — it strengthens your process control and reduces long-term risk.